It was definitely William's fault for tempting the wretch!

In your humble opinion, who is responsible for all of the death and misery in the novel? Is it Victor? Is it the Wretch? Is it little William?

In my own humble opinion, i believe that Victor Frankenstein can be held responsible for all of the death and misery that presented itself in this novel. I'm not taking the Wretch's side out of pity and sympathy, i truly feel that Victor could have prevented all of the tragic events that occurred. He made the final decision on creating the Wretch, and once it had "awoken", he realized the mess that he had created. From that point on, Victor neglected the wretch, pretending that his experiment never happened. This decision was even worse than the prior. This negligence created an animosity between both the creator and the creation. The wretch was like Victor's baby, meaning he needed to be taken care of. Instead, he was left to die, and once the wretch realized that this was his intention, he wanted nothing more than to take revenge.
Victor was not justified in his reaction to his own creation. He had created the monster, of course hoping for positive data during the experiment, so why didn't he realize that his experiment may actually work, and that the body may indeed be filled with life again? He had no reason to fear the wretch. During his awakening, Shelley used imagery to illustrate that the wretch was not initially evil. She wrote,"His jaws opened, and he muttered some inarticulate sounds, while a grin wrinkled his cheeks. He might have spoken, but I did not hear; one hand was stretched out, seemingly to detain me"(59). This quote is important to the story because it not only proves that the Wretch was not inherently evil but was actually born with great admiration for his creator. So in reality, Victor had no reason to disown him. The Wretch showed Victor his appreciation for the gift of life by doing the kindness thing he knew how to do, which was smile. On the other hand, Victor showed the Wretch quite the opposite. He was ashamed of his creation and made it a point to let the daemon know. He showed the Wretch that he was not worthy of any affection in return, altering the creature's mindset completely.
Although the Wretch performed all of the wretched acts seen in the novel, they were provoked by Victor and the cruel towns people whom he was rarely in contact with. "My heart was fashioned to be susceptible of love and sympathy; and when wrenched by misery to vice and hatred, it did not endure the violence of the change, without torture such as you cannot even imagine"(224). The downfall of the Wretch's morality is similar to the training of vicious fighting dogs. You must beat them and hurt them until the only thing left in their minds is hatred. This is similar to the Wretch's situation. Negative event after negative event trained him to feel nothing more than hatred and resentment. So in the end, everything that happened was due to Victor's carelessness. He created the beast and refused to assume responsibility for him, leaving him to fend for himself in the harsh world. Victor tried to cover up his mistakes, but in the end was faced with the harsh reality of what he had done. All of his misery and grief could have easily been prevented, but instead of facing his problens, he ran away like a coward (literally). The devastation caused by the Wretch was ultimately due to Victor's fear and carelessness, relaying the blame from the Wretch back to Victor.